Hy2Care® strives to support the fight against Osteo Arthritis

More about us

Company profile

Hy2Care® is a ‘spin-off company’ of the Tech Med Centre of the University of Twente, the Netherlands and was founded in 2014. Of the original founders, prof. Marcel Karperien and dr. Sanne Both continue to be involved. 

The unique technology of Hy2Care was developed by prof. Marcel Karperien and his team of the Developmental BioEngineering group at the University of Twente. The Injectable Hydrogel technology platform is protected through several patents. Hy2Care’s launching product, the Injectable Patch for Cartilage Repair, is currently being prepared for clinical investigation. Future additional applications are in early-stage R&D phase.

In 2019 Hy2Care received €3.7M Series A funding. It’s current CEO Leo Smit joined, and an additional team expansion was initiated, bringing in also Sanna Severins as Chief Operations Officer and co-director of the company. The goal of the Series A period is to scale up the technology and initiate human trials. Also, a separate product and venture for veterinary applications is under development. 

The company continues to use laboratory facilities in Enschede (NL) at the site of the Twente University of Technology, as well as a laboratory and offices at the Brightlands Chemelot Campus in Geleen.


Hy2Care strives for supporting the fight against Osteo Arthritis by creating solutions for prevention and cure of cartilage damage.


Hy2Care aims to be a leading cartilage repair company, creating solutions with its unique and proprietary injectable hydrogel platform, based on joint tissue mimicking polymers, that allows the body to heal itself.

Quality statement

Hy2Care is committed to its Vision and Mission by striving for a world free of Osteo Arthritis, bringing to market products allowing the body to heal itself. Safety and quality of our products is our top priority, satisfying patient needs and increasing their quality of life. We ensure all our products are compliant with applicable national and international regulations.

To support this, Hy2Care implemented a Quality Management System meeting the requirements according to ISO 13485:2016, which effectiveness is continuously improved.


How it started, where it's going; an overview of the development of our injectable hydrogel platform.

History of Hy2Care


Introducing the diverse group of partners we work with, from Grant-partners to development partners.

Meet our partners


Multi-disciplinary management & scientific founders, merging science and business.

Meet our team